VEGF is a cytokine a small protein released by cells that have specific effects on the behavior of cells which when it interacts with its receptors in the cell leads to new blood vessel formation or angiogenesis. Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice. For information about the 4th Angel Mentoring Program visit www.
Toggle navigation. Spanish About Chemocare. What Avastin Is Used For: Treatment of metastatic colon or rectal cancer, used as part of a combination chemotherapy regimen. Treatment for non-squamous, non-small cell lung cancer. Treatment of metastatic breast cancer used as part of a combination chemotherapy regimen. Treatment of glioblastoma GBM. Treatment of metastatic renal cell carcinoma. The first dose is given over 90 minutes. The infusion time can eventually be shortened to 30 minutes if well-tolerated.
The amount of avastin that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule. Side Effects of Avastin: Important things to remember about the side effects of avastin: Most people do not experience all of the side effects listed.
Side effects are often predictable in terms of their onset and duration. Side effects are almost always reversible and will go away after treatment is complete.
There are many options to help minimize or prevent side effects. There is no relationship between the presence or severity of side effects and the effectiveness of the medication. There is no data as to the frequency of adverse reactions that may be attributed to avastin alone. In clinical studies avastin was used in combination with other chemotherapy medications. This can put you at increased risk for infection. This syndrome is caused by damage to the glomeruli tiny blood vessels in the kidney that filter waste and excess water from the blood and send them to the bladder as urine.
Congestive heart failure in patients who have received prior treatment with anthracycline based chemotherapy, or radiation therapy to the chest wall.
Delayed effects: Based on animal studies, avastin may disrupt normal menstrual cycles and impair fertility by several effects. Some parameters do not recover completely, or recover very slowly following discontinuation of the drug. When to contact your doctor or health care provider: Contact your health care provider immediately , day or night, if you should experience any of the following symptoms: Fever of Contact your health care provider within 24 hours of noticing any of the following: Swelling of the feet or ankles.
Sudden weight gain. Abdominal pain Nausea interferes with ability to eat and unrelieved with prescribed medication. Vomiting vomiting more than times in a 24 hour period. Diarrhea episodes in a hour period. Constipation unrelieved by laxative use. Coughing up blood. Black or tarry stools, or blood in your stools. Blood in the urine. Mouth sores painful redness, swelling or ulcers.
Signs of infection such as redness or swelling, pain on swallowing, coughing up mucous, or painful urination. Unable to eat or drink for 24 hours or have signs of dehydration: tiredness, thirst, dry mouth, dark and decreased amount of urine, or dizziness. Precautions: Before starting avastin treatment, make sure you tell your doctor about any other medications you are taking including prescription, over-the-counter, vitamins, herbal remedies, etc.
Do not receive any kind of immunization or vaccination without your doctor's approval while taking avastin. Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category C use in pregnancy only when benefit to the mother outweighs risk to the fetus.
For both men and women: Do not conceive a child get pregnant while taking avastin. Barrier methods of contraception, such as condoms, are recommended. Federal Government.
Read our disclaimer for details. Results First Posted : May 31, Last Update Posted : May 31, Study Description. Detailed Description:. Drug Information available for: Bevacizumab Ranibizumab. FDA Resources. Arms and Interventions. Ranibizumab is a vascular endothelial growth factor inhibitor designed for ocular use. Bevacizumab is an off-label but cheaper treatment for diabetic macular edema. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
Inclusion Criteria: patients in whom anti-vascular endothelial growth factor VEGF therapy is indicated for the treatment of diabetic macular edema able to return for extra clinic visits according to study schedule Exclusion Criteria: active malignancy previous retinal laser treatment previous anti-VEGF therapy previous vitrectomy. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. Layout table for additonal information Responsible Party: Dr. Sanjay Sharma, Queen's University:. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Diabetic Macular Edema. Drug: Bevacizumab Drug: Ranibizumab. Phase 3.
Study Type :. Interventional Clinical Trial.
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